Improving survival rates for adolescents and young adults with cancer.
One of the challenges for the adolescent and young adult (AYA) cancer population is the transition of adolescent cancer survivors treated at pediatric institutions to adult-based providers in their young adult years. Unfortunately, most AYA survivors are not enrolled and followed in survivorship programs and are oftentimes treated by primary care physicians who are unfamiliar with AYA cancers and the long-term effects and issues associated with them.
Source: Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults with Cancer, Report of the Adolescent and Young Adult Oncology Progress Review Group. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, National Institutes of Health, National Cancer Institute, LIVESTRONG™ Young Adult Alliance; NIH Pub. 06-6067; 2006.
Improved clinical trial enrollment in adolescent and young adult (AYA) oncology patients after the establishment of an AYA oncology program uniting pediatric and medical oncology divisions.
Cancer. 2011 Dec 27;
Authors: Shaw PH, Boyiadzis M, Tawbi H, Welsh A, Kemerer A, Davidson NE, Kim Ritchey A
Abstract
BACKGROUND: Since 1975, there has been a dramatic increase in the survival rates of pediatric and older cancer patients, but adolescent and young adult (AYA) patients ages 15 to 40...
Antitumor effects of YM155, a novel survivin suppressant, against human aggressive non-Hodgkin lymphoma.
Leuk Res. 2011 Jun;35(6):787-92
Authors: Kita A, Nakahara T, Yamanaka K, Nakano K, Nakata M, Mori M, Kaneko N, Koutoku H, Izumisawa N, Sasamata M
Abstract
YM155, a novel small-molecule that down-regulates survivin, exhibits broad, potent antitumor activity against a range of human tumors. We evaluated the activity of YM155 in aggressive non-Hodgkin lymphoma. In a number of diffuse...
End of life care in adolescents and young adults with cancer: Experience of the adolescent unit of the Institut Gustave Roussy.
Eur J Cancer. 2011 Nov 2;
Authors: Cohen-Gogo S, Marioni G, Laurent S, Gaspar N, Semeraro M, Gabolde M, Dufour C, Valteau-Couanet D, Brugières L
Abstract
BACKGROUND: Cancer is the third leading cause of death in adolescents and young adults (AYA). Little is known, however, about how end-of-life unfolds for those who die of progressive disease. In order to...
A social-ecological model of readiness for transition to adult-oriented care for adolescents and young adults with chronic health conditions.
Child Care Health Dev. 2011 Nov;37(6):883-95
Authors: Schwartz LA, Tuchman LK, Hobbie WL, Ginsberg JP
Abstract
Background Policy and research related to transition to adult care for adolescents and young adults (AYAs) has focused primarily on patient age, disease skills and knowledge. Objective In an effort to broaden conceptualization of...
Clinical Trial Participation and Time to Treatment Among Adolescents and Young Adults With Cancer: Does Age at Diagnosis or Insurance Make a Difference?
J Clin Oncol. 2011 Sep 19;
Authors: Parsons HM, Harlan LC, Seibel NL, Stevens JL, Keegan TH
Abstract
PURPOSEBecause adolescent and young adult (AYA) patients with cancer have experienced variable improvement in survival over the past two decades, enhancing the quality and timeliness of cancer care in this population has emerged as a...
Building the bridge between rhabdomyosarcoma in children, adolescents and young adults: The road ahead.
Crit Rev Oncol Hematol. 2011 Jul 28;
Authors: Van Gaal JC, De Bont ES, Kaal SE, Versleijen-Jonkers Y, van der Graaf WT
Rhabdomyosarcoma (RMS) is a rare type of soft tissue sarcoma that mainly affects children, but also occurs in adolescents and (young) adults (AYA). Despite dramatic survival improvements reported by international study groups in children over the past decades, the awareness of a...
Psychiatric illness and virologic response in patients initiating highly active antiretroviral therapy.
J Acquir Immune Defic Syndr. 2007 Feb 1;44(2):159-66
Authors: Pence BW, Miller WC, Gaynes BN, Eron JJ
Mental illness (MI) and substance abuse (SA) are common in HIV-positive patients. MI/SA consistently predict poorer antiretroviral adherence, suggesting that affected patients should be at higher risk of poor virologic and immunologic response to highly active antiretroviral therapy (HAART)....
Challenges in the recruitment of adolescents and young adults to cancer clinical trials.
Cancer. 2007 Dec 1;110(11):2385-93
Authors: Burke ME, Albritton K, Marina N
The adolescent and young adult (AYA) oncology population has seen inferior progress in cancer survival compared with younger children and older adults over the past 25 years. Previously, AYAs had the best survival rates due to the prevalence of highly curable diseases including Hodgkin lymphoma and germ cell tumors, yet today AYAs have...
Current issues in adolescent and young adult cancer survivorship.
Cancer Control. 2008 Jan;15(1):55-62
Authors: Soliman H, Agresta SV
Overall, the survival rate for cancer patients has continued to improve over the past several decades. However, those aged 15 to 29 years have not experienced the same improvements in survival. This review explores some of the challenges faced by adolescent and young adult (AYA) cancer patients and their survivorship needs.
PMID: 18094661 [PubMed -...
Registration and classification of adolescent and young adult cancer cases.
Pediatr Blood Cancer. 2008 May;50(5 Suppl):1090-3
Authors: Pollock BH, Birch JM
Cancer registries are an important research resource that facilitate the study of etiology, tumor biology, patterns of delayed diagnosis and health planning needs. When outcome data are included, registries can track secular changes in survival related to improvements in early detection or treatment. The surveillance, epidemiology, and end...
[Structure and dynamics of the mangrove forest in the Rancheria River delta, Colombian Caribbean].
Rev Biol Trop. 2007 Mar;55(1):11-21
Authors: Lema Vélez LF, Polanía J
We registered seedling survival and biomass increase for Rhizophora mangle L., Avicennia germinans L. and Laguncularia racemosa (L.) Gaertn. f, main mangrove species in the Rancheria River delta, Colombia. Only seedlings of R. mangle were found to survive. We also measured maximum rate of litterfall. We estimated annual litterfall...
Cancer in adolescents and young adults in north Netherlands (1989-2003): increased incidence, stable survival and high incidence of second primary tumours.
Ann Oncol. 2009 Feb;20(2):365-73
Authors: van Gaal JC, Bastiaannet E, Schaapveld M, Otter R, Kluin-Nelemans JC, de Bont ES, van der Graaf WT
Lack of survival improvement in adolescents and young adults (AYA) with cancer has led to increased awareness of this young population. Design: We carried out a population-based study of incidence and...
from patients, caregivers and medical professionals dealing with this disease and many other diseases
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