Improving survival rates for adolescents and young adults (AYAs) with cancer
A chief concern affecting quality of life among young adult (YA) cancer survivors is fertility. Although discussions regarding the possibility of infertility and methods to decrease the risk are crucial at the time of diagnosis, many YAs don’t remember having adequate discussions regarding these topics before the initiation of their treatment. Embryo cryopreservation in women and sperm cryopreservation in men before cancer therapy remains to be the most effective ways in which fertility is preserved in the YA population. Although female and male gonadal tissue cryopreservation and transplantation remain experimental, such options are explored and continuously researched through programs such as the Oncofertility Consortium at Northwestern University.
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Bleyer A, Barr R. Cancer in Young Adults 20 to 39 Years of Age: Overview. Semin Oncol. 2009; 36:194-206.
Will imatinib compromise reproductive capacity?
Oncologist. 2011;16(10):1422-7
Authors: Zamah AM, Mauro MJ, Druker BJ, Oktay K, Egorin MJ, Cedars MI, Rosen MP
Abstract
Imatinib mesylate is the first in a family of highly effective, minimally toxic, targeted agents used widely to treat Philadelphia-positive leukemias and selected other cancers, leading to a steady rise in the prevalence of patients using such therapy. Because failure of therapy would require conventional gonadotoxic...
Fertility preservation in female cancer patients.
ISRN Obstet Gynecol. 2012;2012:807302
Authors: Kim CH, Jeon GH
Abstract
With improved survival rates among cancer patients, fertility preservation is now being recognized as an issue of great importance. There are currently several methods of fertility preservation available in female cancer patients and the options and techniques via assisted reproduction and cryopreservation are increasing, but some are still experimental and...
Fertility preservation for patients with cancer.
Clin J Oncol Nurs. 2012 Apr 1;16(2):205-10
Authors: Kelvin JF, Kroon L, Ogle SK
Abstract
A key concern for young patients with cancer and survivors is the desire to parent a child. With infertility being a well-established long-term effect of many oncologic regimens, patients who want to have children often become distressed when faced with the possibility of losing their fertility. Several organizations have recommended that oncology...
Select interviews from the 2011 San Antonio Breast Cancer Symposium (SABCS) and American Society of Hematology (ASH) Annual Meeting.
Oncology (Williston Park). 2011 Dec;25(14):1422-4, 1426
Authors: Osborne CK, Evens A
PMID: 22329194 [PubMed - indexed for MEDLINE]
Randomized trial using gonadotropin-releasing hormone agonist triptorelin for the preservation of ovarian function during (neo)adjuvant chemotherapy for breast cancer.
J Clin Oncol. 2012 Feb 10;30(5):533-8
Authors: Munster PN, Moore AP, Ismail-Khan R, Cox CE, Lacevic M, Gross-King M, Xu P, Carter WB, Minton SE
Abstract
PURPOSE: Chemotherapy-induced amenorrhea is a serious concern for women undergoing cancer therapy. This prospective randomized trial evaluated the use of gonadotropin-...
Clinical Recommendation Radical Trachelectomy for Fertility Preservation in Patients With Early-Stage Cervical Cancer.
Int J Gynecol Cancer. 2012 Mar 6;
Authors: Schneider A, Erdemoglu E, Chiantera V, Reed N, Morice P, Rodolakis A, Denschlag D, Kesic V
Abstract
ABSTRACT: Radical trachelectomy (RT) is a fertility-sparing procedure with the aim to provide adequate oncological safety to patients with cervical cancer while preserving their fertility. In the current review, indications,...
Effect of cryopreservation and transplantation on the expression of kit ligand and anti-Mullerian hormone in human ovarian tissue.
Hum Reprod. 2012 Feb 7;
Authors: David A, Van Langendonckt A, Gilliaux S, Dolmans MM, Donnez J, Amorim CA
Abstract
BACKGROUNDAlthough cryopreservation and transplantation of ovarian tissue represent a promising alternative to safeguard fertility in cancer patients, low recovery rates of oocytes aspirated from antral follicles and a significant number of...
Malignant ovarian germ cell tumours in gonadal Y chromosome mosaicism.
J Clin Pathol. 2011 Nov;64(11):973-6
Authors: Shahsiah R, Jahanbin B, Rabiei R, Ardalan FA, Sarhadi B, Izadi-Mood N
Abstract
AIMS: Previous studies have shown that two partially overlapping mechanisms are responsible for the development of malignant ovarian germ cell tumours (MOGCT): either spontaneous mutations, mostly in KIT gene, or the presence of Y chromosome material, in dysgenetic gonads. While unilateral...
Recommendations of the Fertility Task Force of the European Society of Gynecologic Oncology about the conservative management of ovarian malignant tumors.
Int J Gynecol Cancer. 2011 Jul;21(5):951-63
Authors: Morice P, Denschlag D, Rodolakis A, Reed N, Schneider A, Kesic V, Colombo N,
Abstract
In young patients with borderline ovarian tumor a conservative treatment approach does not seem to have a significant impact on survival, and the outcome regarding fertility is good in general....
Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants.
PLoS One. 2011;6(4):e19475
Authors: Soleimani R, Heytens E, Oktay K
Abstract
Ovarian transplantation is one of the key approaches to restoring fertility in women who became menopausal as a result of cancer treatments. A major limitation of human ovarian transplants is...
Cancer therapy and fertility preservation.
J Assist Reprod Genet. 2011 Nov 15;
Authors:
PMID: 22083809 [PubMed - as supplied by publisher]
[Ovarian yolk sac tumour: general review].
Bull Cancer. 2011 Aug 1;98(8):963-75
Authors: Even C, Lhommé C, Duvillard P, Morice P, Balleyguier C, Pautier P, Troalen F, de La Motte Rouge T
Abstract
Ovarian yolk sac tumour (OYST) is a very rare malignancy arising most often in young women. Preoperative clinical, biological (alpha-foetoprotein) and radiological findings should help to establish the diagnosis of OYST, in order to propose adequate surgical treatment. The aim of surgery is...
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