Improving survival rates for adolescents and young adults (AYAs) with cancer
One of the challenges for the adolescent and young adult (AYA) cancer population is the transition of adolescent cancer survivors treated at pediatric institutions to adult-based providers in their young adult years. Unfortunately, most AYA survivors are not enrolled and followed in survivorship programs and are oftentimes treated by primary care physicians who are unfamiliar with AYA cancers and the long-term effects and issues associated with them.
Source: Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults with Cancer, Report of the Adolescent and Young Adult Oncology Progress Review Group. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, National Institutes of Health, National Cancer Institute, LIVESTRONG™ Young Adult Alliance; NIH Pub. 06-6067; 2006.
Current issues in adolescent and young adult cancer survivorship.
Cancer Control. 2008 Jan;15(1):55-62
Authors: Soliman H, Agresta SV
Overall, the survival rate for cancer patients has continued to improve over the past several decades. However, those aged 15 to 29 years have not experienced the same improvements in survival. This review explores some of the challenges faced by adolescent and young adult (AYA) cancer patients and their survivorship needs.
PMID: 18094661 [PubMed -...
Challenges in the recruitment of adolescents and young adults to cancer clinical trials.
Cancer. 2007 Dec 1;110(11):2385-93
Authors: Burke ME, Albritton K, Marina N
The adolescent and young adult (AYA) oncology population has seen inferior progress in cancer survival compared with younger children and older adults over the past 25 years. Previously, AYAs had the best survival rates due to the prevalence of highly curable diseases including Hodgkin lymphoma and germ cell tumors, yet today AYAs have...
The effect of community nurses and health volunteers on child mortality: the Navrongo Community Health and Family Planning Project.
Scand J Public Health. 2007;35(6):599-608
Authors: Pence BW, Nyarko P, Phillips JF, Debpuur C
Despite effective treatments and preventive measures for the major causes of child illness and death in less wealthy nations, child mortality remains high in resource-poor settings due in part to ineffective health service delivery models.
PMID: 17852975 [PubMed...
Current treatment of myoclonic astatic epilepsy: clinical experience at the Children's Hospital of Philadelphia.
Epilepsia. 2007 Sep;48(9):1703-7
Authors: Kilaru S, Bergqvist AG
Myoclonic astatic epilepsy (MAE) is a generalized epilepsy of early childhood. Little is known about the use of newer antiepileptic treatments (AET) in MAE. The purpose of this study was to describe the characteristics, treatment, and outcome of a contemporary MAE cohort exposed to the new generation AET.
PMID...
Adolescent and young adult (AYA) oncology: the first A.
Pediatr Hematol Oncol. 2007 Jul-Aug;24(5):325-36
Authors: Bleyer A
Whereas adolescents with cancer as a group used to have a better prognosis than children with malignant disease, trends suggest that the overall survival of 15- to 19-year-olds is now worse than in younger patients. Also, the incidence of cancer is higher in 15- to 19-year age span than during the first 15 years of life. In 2006, the U.S. National Cancer Institute (NCI) and the...
Psychiatric illness and virologic response in patients initiating highly active antiretroviral therapy.
J Acquir Immune Defic Syndr. 2007 Feb 1;44(2):159-66
Authors: Pence BW, Miller WC, Gaynes BN, Eron JJ
Mental illness (MI) and substance abuse (SA) are common in HIV-positive patients. MI/SA consistently predict poorer antiretroviral adherence, suggesting that affected patients should be at higher risk of poor virologic and immunologic response to highly active antiretroviral therapy (HAART)....
Assessing the health care needs of adolescent and young adult cancer patients and survivors.
Cancer. 2006 Dec 15;107(12):2915-23
Authors: Zebrack B, Bleyer A, Albritton K, Medearis S, Tang J
Improvements in cancer outcomes observed for the United States population as a whole are not experienced as such by adolescent and young adult (AYA) patients. The objective of this study was to identify important health and supportive care needs for AYA patients and survivors.
PMID: 17103383 [...
Anxiety, depression, and posttraumatic stress in Iranian survivors of chemical warfare.
JAMA. 2006 Aug 2;296(5):560-6
Authors: Hashemian F, Khoshnood K, Desai MM, Falahati F, Kasl S, Southwick S
In the 1980-1988 Iran-Iraq War, extensive use of chemical weapons resulted in high rates of morbidity and mortality. While much is known about the physical consequences of chemical warfare, there is a paucity of information about the long-term effects of chemical attacks on mental health.
PMID...
Adolescents with acute lymphoblastic leukaemia: emerging from the shadow of paediatric and adult treatment protocols.
Pediatr Blood Cancer. 2006 Nov;47(6):748-56
Authors: Ramanujachar R, Richards S, Hann I, Webb D
Adolescents and young adults (AYA) with acute lymphoblastic leukaemia (ALL) constitute a distinct population from children and older adults. Based on patterns of referral, they may be treated by either paediatric or adult oncologists. As a group, AYA with ALL have a worse survival and...
Expanded role for ARBs in cardiovascular and renal disease? Recent observations have far-reaching implications.
Postgrad Med. 2001 Apr;109(4):115-22; quiz 9
Authors: Ramahi TM
The ARBs are a new class of drugs with broad therapeutic potential in cardiovascular disease. These agents act by selectively inhibiting the AT1 subtype of the angiotensin II receptors. They are effective antihypertensive agents with promise, theoretically, in the prevention and regression of ventricular hypertrophy. They are...
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